Infratentorial IDH-mutant astrocytoma is a distinct subtype
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چکیده
منابع مشابه
Mutant IDH is sufficient to initiate enchondromatosis in mice.
Enchondromas are benign cartilage tumors and precursors to malignant chondrosarcomas. Somatic mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) are present in the majority of these tumor types. How these mutations cause enchondromas is unclear. Here, we identified the spectrum of IDH mutations in human enchondromas and chondrosarcomas and studied their effects in mice. A broad ran...
متن کاملIntegrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched s...
متن کاملInfratentorial benign cystic meningioma mimicking a hemangioblastoma radiologically and a pilocytic astrocytoma intraoperatively: a case report
INTRODUCTION Cystic meningiomas are rare variants of meningiomas; they can pose a radiological diagnostic dilemma. CASE PRESENTATION We present a rare case of a 30-year-old Chinese woman with a histopathological diagnosis of infratentorial cystic meningioma (World Health Organization Grade 1) in which the features in imaging modalities were suggestive of a hemangioblastoma. Intraoperatively, ...
متن کاملLactate dehydrogenase A silencing in IDH mutant gliomas.
BACKGROUND Mutations of the isocitrate dehydrogenase 1 and 2 gene (IDH1/2) were initially thought to enhance cancer cell survival and proliferation by promoting the Warburg effect. However, recent experimental data have shown that production of 2-hydroxyglutarate by IDH mutant cells promotes hypoxia-inducible factor (HIF)1α degradation and, by doing so, may have unexpected metabolic effects. ...
متن کاملSynchronous Pediatric Supratentorial Glioblastoma Multiforme with Noncontiguous Infratentorial Pilocytic Astrocytoma: A Rare Event
The patient underwent left temporoparietal craniotomy and near total decompression of the tumor. The lesion was grayish, soft, and friable with moderate vascularity. Histopathology of the temporal lesion showed a densely cellular neoplasm with cells being round‐to‐ovoid, hyperchromatic, and exhibiting high N:C ratio, scanty, clear to eosinophilic cytoplasm with the areas of necrosis, and microv...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2020
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-020-02194-y